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Defensins are small cationic peptides produced by neutrophils and epithelial cells, playing a crucial role in the innate immune response due to their antimicrobial properties. Recent studies have linked single nucleotide polymorphisms (SNPs) in beta-defensins to an increased susceptibility to cancer. Specifically, downregulation of beta-defensins has been observed in oral cancer, indicating a potential tumor-suppressive role.
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| COFA Description |
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